At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visitneurocrine.com, and follow the company on LinkedIn, X (Formerly Twitter) and Facebook. (*in collaboration with AbbVie)

About the Role:

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• Develop and execute LC-MS/MS bioanalytical methods for the quantification of small molecules, peptides, and proteins in biological samples from in-vivo pharmacokinetic, pharmacology and toxicology studies

• May develop and implement novel LC-MS/MS and LC-HRMS methodologies to analyze drug candidates

• May develop LC-HRMS methods for metabolite identification of protein therapeutics

• May act as a bioanalytical representative on discovery or development teams

• May manage outsourcing of BA/PK/TK studies with external CRO partners

• May contribute to the preparation or review of regulatory submissions and study reports

• May mentor or train less experienced team members

• BS/BA degree in Chemistry or closely related field and 5+ years of industry experience in an biotech, pharma, and/or CRO setting; Experience working in and accomplishing tasks a timeline driven setting; Experience in lab automation is required; Experience in large molecules and biomarkers bioanalysis is preferred OR
• MS/MA degree in Chemistry or closely related field and 3+ years of similar experience noted above OR
• PhD or equivalent and some similar experience as noted above or PostDoc work
• Strong background in bioanalytical job-relevant core competency (instrumental analysis (LC/MS/MS and/or LC/UV), automation, matrix analysis, specialty mass spectrometry techniques, method development/qualification/validation)
• Strong expertise in LC-MS/MS method development, optimization and troubleshooting on Triple Quadrupole (Sciex or similar) and/or Orbitrap HRMS
• Proficiency in sample preparation techniques for biological matrices, such as solid-phase extraction, protein precipitation and affinity purification
• Extensive hands-on experience with role-appropriate technology and methodology such as: automation, LC-MS/MS, PK analysis and modeling and simulation software
• Experience in LC-HRMS for biotransformation/metabolism of protein therapeutics is desirable
• Strong written and verbal communication skills
• Demonstrates solid level of understanding project / group goals and methods
• Consistently recognizes anomalous and inconsistent results and interprets experimental outcomes
• Able to explain the process behind the data and implications of the results
• Strong knowledge of one or more scientific disciplines, becoming expert in one discipline
• Strong knowledge of scientific principles, methods and techniques
• Strong knowledge and demonstrated ability working with a variety of laboratory instrumentation and/or PK analysis and or modeling and simulation software
• Ability to work as part of a team; may train lower levels
• Excellent computer skills
• Strong problem-solving, analytical thinking skills
• Detail oriented and developing understanding of scientific impact on broader team objectives
• Ability to meet multiple deadlines, with a high degree of accuracy and efficiency

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Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

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